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Cancer 27 July 2009

Previous research has found that cancers are significantly more acidic than normal tissues (Raghunand N et al, Novartis Foundation Symposium 2001) and that manipulation of pH with intravenous bicarbonate enhances some chemotherapy (Raghunand N, British Journal of Cancer, June 1999). Acidic tissues are low in oxygen. When alkalinity increases the supply of oxygen to the cancerous tissue, the oxygen combines with the excessive hydrogen ions, creating water and neutralising the acid.

Many complementary practitioners now routinely recommend alkaline foods and sodium bicarbonate to alkalinise the body in cancer treatment. The alkalinity ensures maximum delivery of oxygen to cells and maximum cellular waste elimination. Remember that acid/alkaline basis is measured by the pH on a scale of 1 to 14 and the human body functions optimally at a slightly alkaline pH of 7.365.

Remember that the body is alkaline by design (it functions best at a slightly alkaline pH) but acidic in function (what we eat, drink and think makes us more acidic). The body has alkaline buffers (bicarbonate salts, calcium from bone, magnesium and potassium) to counteract the acidity but over time these systems can be depleted allowing for the development of latent tissue acidosis. It is this acidosis which results in the formation of yeast and fungus in the blood and if allowed to persist, ultimately cancer. Fungus usually begins in the gut through a process known as dysbiosis and then enters the blood. The fact that fungus from the gut can enter the blood stream through the gut wall has been scientifically proven (Infection and Immunity. 1993;61:619-626)

The American Cancer Society has written “mycotoxins are genotoxic carcinogens (i.e they cause cancer by damaging genes) and exposure begins in utero and in mothers milk, continuing through life.” (American Cancer Society Textbook of Clinical Oncology).

Medical journals have long recognised this link between mould, mycotoxins and illness: “Mycotoxins have proven to be very toxic and harmful and it is no wonder that many inhabitants of mould infested spaces are constantly ill, mainly with upper respiratory tract infections, lethargy, constant headaches, nausea and a general ill feeling. Inhabiting these living spaces for a considerable period may lead to cancer.” (Przegl Lek 2000;57(7-8):419-23).

There is also direct evidence for the fungal:cancer link in the scientific literature. A presentation at the September 1999 Interscience Conference on Antimicrobials and Chemotherapy documented several cases of children with leukemia going into remission when they received anti-fungal treatment for their “secondary” fungal infections. Milton White MD published in the 1996 Medical Hypothesis journal that he found fungal spores in every sample of cancer tissue he studied. This mirrors my findings as well.

Surprisingly, orthodox medicine has no way of accurately determining the presence of invasive fungal disease- “There are no rapid, accuarte diagnostic tests that can confirm with certainty the presence of invasive fungal disease.” (John Rex MD. Managing fungal infections in the new millenium. Medscape.com April 2000).

The recent papers also suggest that part of any successful cancer treatment should always include detoxification of heavy metals and toxic chemicals which are pervasive in our environment. A 1973 study found that when cancerous breast tissue is compared to non-cancerous tissue in the same womans body, the concentration of toxic chemicals such as DDT and PCB’s was much higher in the cancerous tissue.

Moderate exercise is a crucial part of any anti-cancer regime as well. This is because it is a powerful way of reducing metabolic acids in the body (while extreme exercise increases them) and because studies have shown that even 10 minutes of walking turns on a gene that decreases cancer growth rate.

Finally, for those of you who would like scientific evidence, listed below is a few studies documenting the link between pH imbalance and cancer.

Studies relating to the antacid power of sodium bicarbonate in tumours:

Anne McLean, “Malignant gliomas display altered pH regulation by NHE1 compared with non transformed astrocytes (Am J Physiol Cell Physiol 278: C676-C688, 2000).

Marion Stubbs, “Causes and consequences of tumour acidity and implications for treatment”, Molecular Medicine: Today, January 2000 (vol.6).

Robert J. Gillies, “Causes and consequences of hypoxia and acidity in tumors – Novartis Foundatíon symposium”, Molecular Medicine Vol.7 N° 2 February 2001; “Causes and consequences of hypoxia and acidity in tumour microenvironments”.

J.R. Griffiths, “Causes and consequences of hypoxia and acidity in tumour microenvironments”, Glia 1994 Nov:12(3):196-210.

Tannock, I.F., “Acid pH in tumors and its potential for therapeutic exploitation”
Cancer Res 1989 Aug 15;49(16):4373-84.

Raghunand, N., “Enhancement of chemotherapy by manipulation of tumour pH”
Br J Cancer 1999 Jun;80(7):1005-11.

Davydova, I.G., “Dynamics of bioelectric activity of the brain and erythrocyte ultrastructure after intravenous infusion of sodium bicarbonate to oncologic patients.” Biull Eksp Biol Med 1992 Apr;113(4):352-5.

Davydova, I.G., “Characteristics of the effects of artificial alkalosis on electrical activity of the brain and ultrastructure of blood cells in oncologic patients”, Vestn Ross Akad Med Nauk 1995;(4):24-5.

Star, R.A., “Regulatory volume decrease in the presence of HCO3- by single osteosarcoma cells UMR-106-01”, J Biol Chem 1992 Sep 5;267(25):17665-9.

LeBoeuf, R.A., “Intracellular acidification is associated with enhanced morphological transformation in Syrian hamster embryo cells”, Cancer Res 1992 Jan 1;52(1):144-8.

Raghunand, N., “Acute metabolic alkalosis enhances response of C3H mouse mammary tumors to the weak base mitoxantrone.” Neoplasia. 2001 May-Jun;3(3):227-35.

Raghunand, N., “pH and chemotherapy pH and chemotherapy” Novartis Found Symp. 200 1;240:199-21 l; discussion 265 -8.

Raghunand, N., “Enhancement of chemotherapy by manipulation of tumour pH.” Br J Cancer. 1999 Jun;80(7):1005-1 I.

Raghunand, N., “Tumor acidity, ion trapping and chemotherapeutics. IL pll-dependent partition coefficients predict importance of ion trapping on pharmacokinetics of weakly basic chemotherapeutic agents.” Biochem Pharmacol. 2003 Oct 1;66(7):1219-29.”

Mahoney, B.P., “Tumor acidity, ion trapping and chemotherapeutics. I. Acid pII affects the distribution of chemotherapeutic agents in vitro.” Biochem Pharmacol. 2003 Oct 1;66(7):1207-18.

Schornack, P.A., “Contributions of cell metabolism and H+ diffusion to the acidic pH of tumors.” Neoplasia. 2003 Mar-Apr;5(2):135-45.

Giffles, R.J., “MRI of the tumor microenvironment.” J Magn Reson Imaging 2002 Dec; 16(6):75 l.

Torigoe, T., “Vacuolar H(+)-ATPase: functional mechanisms and potential as a target for cancer chemotherapy.” Anticancer Drugs. 2002 Mar; 13 (3):23 7-43.

Griffiths, J.R., “Why are cancers acidic? A carrier-mediated diffusion model for H+ transport in the interstitial fluid.” Novartis Found Symp. 200 1;240:46-62; discussion 62-7, 152-3.

Webb, S.D., “Modelling tumour acidity and invasion.” Novartis Found Symp. 2001;240:169-8 l; discussion 181-5.

Gillies, R.J., “The tumour microenvironment: causes and consequences of hypoxia and acidity. Introduction.” Novartis Found Symp. 200 1;240:1-6.

Gillies, R.J., “Causes and consequences of hypoxia and acidity in tumors” Novartis Foundation symposium. Trends Mol Med. 2001 Feb;7(2):47-9.

Griffiths, JR. “Causes and consequences of hypoxia and acidity in tumour microenvironments. Bioessays. 2001 Mar;23(3):295-6.

Gillies, R.J., “Causes and effects of heterogeneous perfusion in tumors.” Neoplasia. 1999 Aug; 1 (3):197-207.

Stubbs, M., “Causes and consequences of tumour acidity and implications for treatment.” Mol Med Today. 2000 Jan;6(1):15-9

Stubbs, M., “Causes and consequences of acidic ph in tumors: a magnetic resonance study.” Adv. Enzyme Regul. 1999;39;13-30.

Webb, S.D., “Mathematical modelling of tumour acidity: regulation of intracellular pH.” J Theor Biol. 1999 Jan 21; 196(2);237-50.

Yamagata, M., “The contribution of lactic acid to acidification of tumours: studies of variant cells lacking lactate dehydrogenase.” Br J Cancer. 1998 Jun;77(11):1726~3 I.

Martin, G.R., “Non invasive measurement of interstitial pH profiles in normal and neoplastic tissue using fluorescence ratio imaging microscopy.” Cancer Res. 1994 Nov 1;54(21):5670-4.

Boyer, M.J., “Regulation of intracellular pH in subpopulations of cells derived from spheroids and solid tumours.” Br J Cancer. 1993 Nov;68(5):890-7.

Newell, K., “Studies with gIycolysis-deficient celIs suggest that production of lactic acid is not the only cause of tumor acidity.”

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